Hormones / Messengers

ACTH may occur in pituitary adenomas, medullary thyroid carcinomas, bronchial carcinoids, pancreatic islet cell tumors and gastric carcinoids.

Adrenomedullin, a peptide originally isolated from from human pheochromocytoma, shares some homology with CGRP. The antiserum was raised using synthetic peptides. No cross-reaction with CGRP.

In man, alpha-MSH is found in corticotrophs of the anterior pituitary and may also occur in brain neurons.

In man, alpha-MSH is found in corticotrophs of the anterior pituitary and may also occur in brain neurons.

Amylin or islet amyloid polypeptide (IAPP) is produced in the pancreatic beta cells and co-released with insulin. The amino acid sequence shows strong homology with CGRP.

beta-endorphin occurs in cells in the anterior pituitary; beta-endorphin may be detected in tumors of the pituitary, gastrointestinal and bronchial carcinoids.

ß-endorphin occurs in most tumors of the pituitary and in bronchial and gastrointestinal carcinoids. No cross-reaction with beta-lipotropin.

The antiserum was raised against synthetic frog bombesin conjugated to bovine thyroglobulin. Suitable for the study of endocrine differentiation in tumors of the respiratory tract.

Bombesin/GRP is widely distributed in the brain, in peripheral nerves and in endocrine cells of some mammalian species and birds. Bombesin/GRP occurs frequently in bronchial carcinoids..