Suchergebnisse für 'actin'

Specific for skeletal and non-muscle actin isoforms (Mr 43,000). The antibody also detects nuclear actin isoforms. Epitope location: NVPAMYVAVLDSGVTHNVPIYHAIMRLDLA.

Specific for F-actin capping protein (a3 subunit; MW 33,740, pI 6.36, calculated from sequence data; Mr 37,000 on SDS-PAGE)

Specific for drebrin isoforms E2 and A, widespread actin-associating proteins of 70 kD (SDS-PAGE mobility shows Mr 120,000). Drebrin has originally been described only in neuronal cells, but has been found also in the actin-rich lamellipodia and filopodia of motile cells. It is enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. Negative: hepatocytes, cross-striated muscle.

Specific for actin related protein T2 (Arp-T2). MW 41,701; pI 5.28, calculated from sequence data; Mr 40,000 on SDS-PAGE.

Protein standard for immunoblotting, immunization and immunoassays.

Marker for the discrimination of cardiac (fetal) alpha-actin from other actin isoforms present in skeletal and smooth muscle. Fetal actin can be localized in regenerating muscle after injury (satellite cells).

Localizing to plasma membrane attachment sites of intermediate filaments and microfilaments (actin), such as desmosomes and hemidesmosomes, Z-line structures and dense plaques of striated and smooth muscle.

ASM-1 represents an excellent marker for myogenic soft tissue tumors and smooth muscle differentiation. Stains leiomyosarkoma, leiomyoma, certain stromal cells surrounding infiltrating ductal carcinoma of breast.

Hochempfindlicher und spezifischer Biomarker für die Diagnose von Herzmuskelerkrankungen und zur Früherkennung bei Myokardinfarkt.