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anti-AAV8 (intact particle) mouse monoclonal, ADK8

For characterization of different stages of infection and very useful for analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in immunoblotting.

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€222.00
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Additional Information

Additional Information

Cat. No. 651160
Antibody Type monoclonal
Suitable for Dot Blots, ELISA, IF, IHC, IP, Neutralisation Assay / frozen sections
Clone ADK8
Dilution prediluted for IHC, IF
Host mouse
Quantity 5 mL
Species / Reactive with AAV8, monkey
Synonym Adeno-associated virus 8; AAV-8
Isotype IgG2a kappa
Presentation supernatant

Product Description

Details

For characterization of different stages of infection and very useful for analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in immunoblotting.

Reference

Reference

Kuck D, Kern A, Kleinschmidt JA (2007). Development of AAV serotype-specific ELISAs using novel monoclonal antibodies. J Virol Methods 140, 17-24

Sonntag F, Köther K, Schmidt K, Weghofer M, Raupp C, Nieto K, Kuck A, Gerlach B, Böttcher B, Müller OJ, Lux K, Hörer M, Kleinschmidt JA: The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes. J Virology 85, 12686-12697 (2011)

Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M: Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. J Virology 86, 7739-7751 (2012)

Raupp C, Naumer M, Müller OJ, Gurda BL, Agbandje-McKenna M, Kleinschmidt JA: The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing. J Virol 17, 9396-9408 (2012); doi:10.1128/JVI.00209-12

Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R: OneBac: Platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Hum Gene Ther 25, 212-222 (2014); doi: 10.1089/hum.2013.184

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